摘要
骨髓间充质干细胞具有自我复制、未分化的特点,并可在不同条件下分化为中胚层起源的多种细胞,是一种成体多能干细胞。就组织工程而言,良好的种子细胞是组织工程技术的关键,骨髓间充质干细胞的性质决定了其在骨组织工程领域中的重要地位。此外,骨骼系统属于机体的运动系统,承担体重是骨骼的重要功能之一;而且,人体内几乎所有的细胞都会受到力学因素的影响,故有必要研究力学因素对骨髓间充质干细胞诱导分化为成骨细胞的作用,为骨髓间充质干细胞的体外扩增、诱导分化及培养提供一种新途径。
Bone marrow-derived mesenchymal stem cells (BMSCs) are a population of cells capable of replicating as undifferentiated cells and that have the potential to differentiate to lineages of mesoblastic origin. As such, they represent an important paradigm of multipotent adult stem cells. Cells are a key to tissue engineering, and the character of BMSCs have impacted significantly on the progress of the tissue regeneration and repair. Furthermore, skeleton system is the locomotion part of the organism, and it's primary function is supporting; moreover, complex mechanical forces are clearly involved in cell development in vivo. Therefore, it is necessary to investigate the effect of strain on proliferation and differentiation of BMSCs, and may provide increased insight in the role of strain on osteogenic differentiation of BMSCs in vitro and lead to improved strategies in bone tissue engineering.
出处
《细胞生物学杂志》
CSCD
北大核心
2004年第6期603-607,共5页
Chinese Journal of Cell Biology
基金
国家自然科学基金资助项目(No.10172093)重庆大学生物力学与组织工程教育部重点实验室访问学者基金资助
