摘要
目的 观察艾司洛尔复合硝普钠用于老年人颅脑手术控制性降压的效果及安全性。方法 4 0例择期颅脑手术病人随机分为两组 :A组 (对照组 )用硝普钠 (SNP)降压 ;B组为艾司洛尔、SNP复合组。降压标准为平均动脉压 (MAP)降低 35 %～ 4 0 %。同步采集动脉血和颈内静脉血作血气分析 ,计算动 静脉血氧含量差 (Da vO2 )、脑氧摄取率 (ERO2 )和硝普钠总用量。结果 B组血压容易下降和维持。B组MAP明显低于A组 ,P <0 0 5 ;B组各个时点心率 (HR)、心率 收缩压乘积 (RPP)小于A组 ,P <0 0 1;硝普钠总用量B组明显少于A组 ;Da vO2 、ERO2 两组之间及降压前、中、后各时段无显著性差异 (P >0 0 5 )。结论 艾司洛尔复合硝普钠控制性降压效果明显优于单用硝普钠 ,两药并用对脑氧供需及脑氧摄取率平衡没有明显影响。
Objective To observe the effect of hypotensive anesthesia by using esmolol and nitroprosside in the old neurosurgical patients.Method Forty neurosurgical patients have been divided by using nitroprosside(group A) and nitroprosside combined esmolol(group B).The heart rate,blood pressure,and RPP have been monitored during operation.Blood analysis and Da-vO 2,ERO 2 have been calculated from mixture internal jugular vein blood.Results The blood pressure,HR、RPP have been controlled stably in group B and the MAP lower then group A.Da-vO 2,ERO 2 have no significantly difference between group A and B.Conclusion Hypotension anesthesia have been performed by using esmolol combined nitroprosside have more advantage and can be safety used in the old neurosurgical patients.
出处
《福建医药杂志》
CAS
2004年第6期33-35,共3页
Fujian Medical Journal
