摘要
目的调查不同出生体重儿成年后代谢异常的现患率,探索两者的关系.方法对上海市平凉社区糖尿病流行病学调查中15～74岁有确切出生体重记录的1 010名中国人(男性390例,女性620例)检测体重指数、腰围、臀围、腰臀比、血压、空腹血糖、胆固醇、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇.以单变量及多变量分析方法观察不同出生体重儿成年后代谢异常的差别及两者的关系.结果低出生体重者(<2.5 kg)56人,高出生体重者(≥4 kg)53人、正常出生体重者901人.低出生体重组成年后BMI均高于正常出生体重组,其中女性体质指数和腰围、腰臀比两组差异有统计学意义(P<0.01).男性高出生体重组成年后腰围和臀围均较正常出生体重组高,两组差异有统计学意义(P<0.05);低出生体重组成年后肥胖、高胆固醇血症、糖尿病及糖尿病合并高血压的患病率均高于正常出生体重组(P<0.05、P<0.01、P<0.05、P<0.01),高出生体重组成年后肥胖发生率和高血压患病率均高于正常出生体重组(P<0.05);低出生体重与成年后超重肥胖、腹型肥胖、高胆固醇血症及糖尿病的发病呈显著性相关.结论低出生体重与成年后肥胖、糖脂代谢异常相关,是成年后发生超重肥胖、高胆固醇血症和糖尿病的危险因素.
Objective To investigate the prevalence of abnormal metabolism in adults with varied birth weights in Pingliang community of Shanghai and to explore association of birth weight and abnormal metabolism during adulthood.Methods A total of 1 010 individuals (390 men and 620 women, aged 15~74 years) with birth weight recorded were selected from Pingliang community in Shanghai. All subjects were interviewed, their height, weight, waist and hip circumferences and blood pressure measured, body mass index (BMI) and waist/hip ratio (WHR) calculated, and levels of fast plasma glucose and lipids measured. Uni- and multivariate analyses were used to estimate the prevalence of abnormal metabolism and to assess the association of the birth weight and abnormal metabolism during adulthood.Results Fifty-six of 1 010 subjects had low birth weight (less than 1.5 kg . LBW), 53 high birth weight (greater than 4 kg, HBW) and 901 normal birth weight (NBW). BMI of the subjects with LBW were higher than those with NBW. There was signifcant difference in BMI, waist and hip circumferences between the women with LBW and NBW (P<0.01). Waist and hip circumferences were significantlu higher in the men with HBW than in those with NBW (P<0.05 ). Prevalence of obesity, hypercholesteremia,type-2 diabetes and type-2 diabetes complicated with hypertension during adulthood were all significantly higher in the subjects with LBW than in those with NBW (P<0.05, P<0.01, P<0.05 and P<0.01). Prevalence of obesity and hypertension during adulthood was higher in the subjects with HBW than in those with NBW (P<0.05). Prevalence of overweight, obesity, hypercholesteremia and type-2 diabetes during adulthood corrlated significantly with their LBW.Conclusions Obesity, and abnormal carbohydrate and fat metabolism during adulthood correlated to their LBW, which possibly was an important risk factor associated with overweight, obesity, hypercholesteremia and type 2 diabetes during adulthood.
出处
《中华全科医师杂志》
2005年第1期17-19,共3页
Chinese Journal of General Practitioners
