摘要
目的探讨部分液体通气(partialliquidventilation,PLV)不同氟碳(perfluorocarbon,PFC)供给途径时血流动力学及血气的改变。方法采用肺灌洗诱导急性肺损伤(acutelunginjury,ALI)后,动物分三组①PFC滴入组;②PFC灌入组;③对照组。分别在ALI前,ALI及ALI后1、2、3、4h7个时段观察HR、MAP、PETCO2等血流动力学指标以及血气变化。结果肺灌洗后三组动物PaO2显著降低、AaDO2显著升高,两组PLV灌注PFC后PaO2升高、肺泡动脉氧压差(AaDO2)显著降低,与对照组比较具有统计学差异(P<0.05),且PFC滴入组2h后各时段与PFC灌入组相应时段比较具有统计学意义(P<0.05)。各组血流动力学无显著性改变(P>0.05)。结论在相同剂量不同的PFC供给途径时部分液体通气,滴入组血气改善的效果明显好于灌入组,但对血液动力学均无显著影响。
s] Objective To observe the changes of hemodynamics and blood gas in different carring way with PFC during partial liquid ventilation. Methods After induction of acute lung injury by saline lavage,the animals were divided randomly into 3 groups: ①instillation group of perfluorocarbon; ②infusion group of perfluorocarbon; ③control group. Record the changes of hemodynamics and blood gas in seven period of times during PLV. Results The PaO_2 significantly improved and AaDO_2 significantly decreased with PFC during PLV compared with control group(P<0.05);The PaO_2 and AaDO_2 changed significantly between the instillation group and infusion group of PFC after two hours during PLV(P<0.05).Conclusion Under the same dosage and different carring way of PFC,the improvement of blood gas is better in the instillation group than in the infusion group,but there were no obvious differences in hemodynamics. [
出处
《中国急救医学》
CAS
CSCD
北大核心
2005年第2期109-111,共3页
Chinese Journal of Critical Care Medicine
基金
广东省医学科研基金课题(A2004348)
2003年暨南大学校基金青年项目
广东省自然科学基金(021178)
关键词
部分液体通气
氟碳
急性肺损伤
Partial liquid ventilation
Perfluorocarbon(PFC)
Acute lung injury
