摘要
目的 制备盐酸伪麻黄碱和萘普生钠复方镶嵌缓释片,并研究其体外释放特性。方法 以亲水凝胶(ＨＰＭＣＫ100Ｍ)为缓释部分基质,采用二次压片的工艺研制了盐酸伪麻黄碱和萘普生钠复方镶嵌缓释片;以磷酸盐缓冲液(ｐＨ7.2)为释放介质,采用紫外分光光度法和酸性染料比色法分别测定了释放液中萘普生钠和盐酸伪麻黄碱的含量,并计算其体外释放度。结果 自制盐酸伪麻黄碱和萘普生钠复方镶嵌缓释片中萘普生钠在0 .5ｈ的释放量大于75%,盐酸伪麻黄碱在0 5ｈ的累积释放约7%±3. 6%,1ｈ为15. 8%±2 .3%,4ｈ为49 .5%±3 .9%,8ｈ在85%以上。结论 该复方镶嵌缓释片兼具速释和缓释特点,效果显著。
OBJECTIVE To prepare Compound pseudoephedrine hydrochloride sustained-release inlay tablet and study its releasing characteristics in vitro. METHODS Compound pseudoephedrine hydrochloride sustained-release inlay tablets were prepared by twice-compressing technology using HPMC as the matrix of sustained-release part. With pH 7.2 phosphrate buffer solution as the media,the specific UV spectrophotometric and colorimetric methods were employed to determine naproxen sodium(NPS-Na)and pseudoephedrine hydrochloride( PE-HCl) in vitro, respectively. Their accumulated release percentages were calculated simultaneously. RESULTS NPS-Na released more than 75% in 0.5 h,while PE-HCl released 7%±3.6% in 0.5 h, 15.8%±2.3% in 1 h, 49.5%±3.9% in 4 h and more than 85% in 8 h。CONCLUSION Compound pseudoephedrine hydrochloride sustained-release inlay tablets exhibite prominent sustained-release and rapid release characteristics in vitro.
出处
《华西药学杂志》
CAS
CSCD
北大核心
2005年第1期18-20,共3页
West China Journal of Pharmaceutical Sciences
