摘要
目的探讨肺癌患者血清及胸腹水中血管内皮生长因子(VEGF)的临床意义。方法应用酶联免疫法检测55例肺癌患者 VEGF 水平,同时测定16例肺癌患者术后1个月的 VEGF 浓度。结果肺癌患者血清中 VEGF 浓度为(86.27±38.20ng/L)(±s),明显高于血清对照组(P<0.01);胸腹水中 VEGF 浓度为(157.51±58.57ng/L)(±s),明显高于良性疾病胸腹水组(P<0.01)。16例肺癌患者术后1个月测定 VEGF 浓度,有11例 VEGF 浓度下降,5例 VEGF 浓度升高,升高组和下降组手术前后测定值差异均有显著性(P<0.01)。结论 VEGF 浓度测定对肺癌的辅助诊断及检测术后膊瘤复发和转移有一定的临床意义。
Objective To evaluate the significance of detection of serum vascular endothelial growth faetor(VEGF)of patients with lung carcinoma.Methods The VEGF was measured by sand- wich ELISA in 55 patients with lung carcinoma and in 16 patients at 1 month after operation.Results The serum VEGF levels of lung carcinoma were 86.27±38.20ng/L(x±s),which were significantly higher than those of serum subjects(P<0.01).The serous membrane fluid VEGF level of lung carci- noma was 157.51±58.57 ng/l(x±s),which was significantly higher than that of benign disease ascites subjects(P<0.01).In 16 patients with lung carcinoma,11 of them had VEGF levels decreased while 5 of them had VEGF levels increased at 1 month after operation.The significant difference in VEGF lev- els was observed between the decreased group and the increased group(P<0.01).Conclusion The VEGF level is an assisting diagnostic marker for lung carcinoma,and it is helpful to inspect relapse and metastasis of tumor after operation.
出处
《检验医学与临床》
CAS
2004年第2期60-61,63,共3页
Laboratory Medicine and Clinic
