摘要
目的:观察特发性非特异性间质性肺炎(INSIP)的显微和超微结构特点以及与肺纤维化发生的关系。方法:对7例INSIP患者经电视胸腔镜(VATS)取肺病理活检组织进行光镜和透射电镜观察。结果:光镜观察肺间质呈不同程度的炎症和纤维化,浸润的细胞主要是淋巴细胞和浆细胞。电镜观察查见Ⅱ型肺泡上皮增生,基底膜增厚,肺泡中隔内纤维细胞增生和胶原纤维沉积,淋巴细胞、浆细胞和巨噬细胞浸润,肥大细胞脱颗粒;纤维化型有明显的平滑肌和肌纤维母细胞增生。结论:INSIP以成熟的纤维细胞增生为主,多种细胞成分参与了肺纤维化的发生过程。
Objective:To observe the microscopic and ultrastructural features of idiopathic nonspecific interstitied pneumonia(INSIP) and its relation with pulmonary interstitial fibrosis. Methods:Samples of lung biopsy tissue of seven cases with INSIP taken by video-assisted thoracoscope were observed under the light microscope(LM) and electron miscroscope(EM).Results:The histologic features of INSIP were varying degrees of pulmonary interstitial imflammation and fibrosis, and prominently infiltrated with lymphocytes and plasma cells. The ultrastructural features of INSIP showed hyperplasia of typeⅡpneumocytes, with proliferation of fibrocytes, deposition of collagenous fibers, and infiltration of lymphoctytes, plasma cells and macrophages in the alveolar septa. Mast cells degranulated could be seen frequantly. In the firbrosing pattern of INSIP, prominent hyperplasia of smooth muscles and myofibroblasts occurred. Conclusions:The hyperplasia of the mature fibrocytes was the main feague of the interstitial fibrosis of INSIP. Multi-cellular element may be associated with the processes.
出处
《电子显微学报》
CAS
CSCD
北大核心
2004年第6期637-641,共5页
Journal of Chinese Electron Microscopy Society
基金
上海市科学技术委员会科研基金资助项目(No.034119868).
