摘要
目的 探讨不同剂量美托洛尔对慢性充血性心力衰竭的疗效及耐受性。方法 197例慢性充血性心力衰竭(CHF)患者在常规传统治疗基础上口服美托洛尔,按美托洛尔日用总量分为 2组,≥100mg/d为高剂量组(n=85),≤75mg/d为低剂量组(n=112),对治疗前、治疗后 12周和 24周做心功能评估及耐受性比较,并做心脏彩色超声心动图,对各项心功能参数进行比较。结果 低剂量组开始治疗 12周后LVEF有改善,但总体状况改善不明显,治疗 24周后状况大致同 12周。高剂量组治疗12周后各项心功能指标均明显改善。高剂量组耐受性略差于低剂量组,差异具有显著意义 (P<0.05),但均无恶性不良事件发生。结论 高剂量组在改善心功能、改善心肌重构方面优于低剂量组,所以只要患者在耐受范围内应尽可能使美托洛尔达到目标剂量。
Objective To investigate the effects and tole ra nce of different doses of metoprolol on congestive heart failure (CHF).M ethods Metoprlol was orally administrated in 197 CHF patients at the ba sis of routine therapy.The patients were divided into hige-dose group (metoprol ol≥100 mg/d,n=85) and low-dose group (metoprolol≤75 mg/d,n=112).The e valuation of cardiac function and a comparison of tolerance of metoprolol were m ade before treatment and 12 weeks,24 weeks after treatment with metoprolol.Besid es,a comparison of parameters of cardiac function was also made by cardiac echocardiography.Results In low-dose group,there were some imp rovements in LVEF after 12-week's treatment,which were not significant on the 1 2th week and 24th week after treatment.In high-dose group,however, the paramet ers of cardiac function were obviously improved.The tolerance to meloprolol in h igh-dose group was less than that in low-dose group,there was a significant di fference between two groups(P<0.05),without severe adverse effects in both groups.Conclusion The high-dose group is superior to low-dose group in the improvement of cardiac function and remodeling of cardiac muscle,s o metoprolol should be added to target doses as much as possible within the tole rance of metoprolol in CHF patients.
出处
《疑难病杂志》
CAS
2005年第1期7-9,共3页
Chinese Journal of Difficult and Complicated Cases
