摘要
目的 :探讨子宫颈癌患者治疗前D二聚体 (DD)在血浆中的水平与手术 -病理分期、肿瘤大小、组织学分型和淋巴节状态的相关性。方法 :测定了 4 8例子宫颈癌患者术前血浆中D -二聚体 (DD) ,患者均进行了子宫完全切除术和骨盆淋巴结切除术。患者术后病理分期 ,Ⅰb 2 1例 ,Ⅱa 12例 ,Ⅱb 15例 ;肿瘤大小 :2 6例患者≤ 4cm ,2 2例 >4cm ;组织学分型 :鳞癌 39例 ,腺癌 9例 ;13例骨盆淋巴结阳性。结果 :术后病理分期Ⅱb患者的血浆DD水平明显高于正常对照组 ,但Ⅰb ,Ⅱa患者升高不明显。血浆DD水平与手术病理分期 (Ⅱb相对于Ⅰb、Ⅱa ,P <0 .0 0 1)和肿瘤大小(>4cm相对于≤ 4cm ,P <0 .0 0 5 )相关。结论 :Ⅱb期子宫颈癌患者DD在血浆中的水平明显升高。
Objective: To explore the relationship between the pretreatment plasma level of D-dimer with tumor stage, size, histological type, and lymph node status in patients with cervical cancer. Methods: The preoperative plasma level of D-dimer(DD) was measured in 48 patients with cervical cancer undergoing radical hysterectomy with pelvic lymphadenectomy. The surgical-pathological stage of disease was Ⅰb in 21 patients, Ⅱa in 12 patients,and Ⅱb in 15 patients. The tumor size was≤4㎝ in 26 patients and >4㎝ in 22 patients. The histological type was squamous cell carcinoma in 39 patients and adenocarcinoma in 9 patients. Positive pelvic lymph nodes were found in 13 patients. Results: To compared with controls, DD level was significantly raised in patients with surgical-pathological stage Ⅱb disease but not in patients with stage Ⅰb or Ⅱa disease. The values of DD were related to surgical-pathological stage (stageⅡb vs stageⅠb-Ⅱa:P<0.001) and tumor size (>4cm vs ≤4cm,P<0.005). Conclusions: Significantly increased DD level occur in patients with stage Ⅱb. Measurement of preoperative DD level would be useful in the preoperative diagnosis of tumor stage.
出处
《青海医药杂志》
2004年第12期7-9,共3页
Qinghai Medical Journal
