摘要
目的 :通过经颅多谱勒 (TCD)、脑电图、记忆量表研究阻塞性睡眠呼吸暂停患者 (OSAS)的发生、认知状况及认知障碍的可能机制。方法 :受试者分为OSAS组 (n =30 )及正常对照组 (n =15 ) ,均进行睡觉多导仪 (PSG)、TCD、脑电图、临床记忆量表检查及神经系统查体。采用t检验和Spearman等级相关分析分析所得数据。结果 :OSAS组、对照组记忆商 (MQ)分别为 90± 12、10 4± 16 ,对照组大脑中动脉 [左 (6 3.81± 13.12 )cm/s,右 (6 0 .6 1±10 .2 3)cm/s],基底动脉 [(42 .6 7± 8.0 2 )cm/s]的平均血流速度及脉动指数与研究组比较差异有显著性 (t =6 .8,11.3,P <0 .0 5或 0 .0 1)。结论 :阻塞性睡眠呼吸暂停患者有认知功能损害 ,夜间低氧血症可能起了重要作用。
Objective:To evaluate cerebral blood flow and electroencephalogram in patients with obstructive sleep apnea syndrome (OSAS) and to explore its possible mechanisms.Methods: The two groups, consisting of the OSAS group(n=30) and control group (n=15) were examined by polysomnography(PSG) aduditory, transcranal Doppler(TCD), electroencephalography(EEG), and clinical memory test.The results were analyzed with test and seaming rank correlation.Results: Memory quotient(MQ) of OSAS group and control group to part for 90±12、104±16, control group middle cerebral artery left(63.81±13.12) cm/s, righ (60.61±10.23)cm/s, basilar artery [(42.67±8.02) cm/s],There were significant difference in the indices of cerebral blood flow between the two groups (t=6.8,11.3,P<0.05或0.01).Conclusion: The OSA patients have cognitive dysfunctions,nocturnal hypoxemia may play an important role.
出处
《实用临床医学（江西）》
CAS
2005年第1期24-26,共3页
Practical Clinical Medicine
