摘要
目的 通过对用药前后病人收缩压、血肌酐、血尿素氮的观察 ,研究非洛地平 (波依定 )单药或联用美托洛尔 (倍他乐克 )对老年人单纯收缩期高血压病人的血压控制率及肾功能的影响。方法 78名入围调查期病人采取分步治疗方案 ,目标血压为收缩压小于 14 0mmHg ,统计波依定(5～ 10mg/d)单药控制率及联用倍他乐克 (2 5～ 5 0mg/d)的血压控制率 ,用药前后监测病人的血肌酐、血尿素氮 ,采用t检验进行显著性分析。结果 波依定 (5～ 10mg/d)单药控制率 :80 77% (6 3/ 78) ;联用倍他乐克 (2 5～ 5 0mg/d)后控制率 :94 87% (74 / 78)。用药前后血肌酐、血尿素氮t检验P >0 0 5 ,统计学无显著性差异。结论 波依定对老年人单纯收缩期高血压有理想的血压控制率 ,联用倍他乐克作用更佳 ,副作用轻微 ,对病人肾功能无不良影响。
Objectives To observe the systolic pressure, creatine and bun in blood sample before or after medication in order to study the rate of control systolic hypertension and effect on renal function in geronatal patients with treatment of single felodipine (plendil) or combined with betaloc. Methods Plendil (5 mg/d) was used singly or combined with betaloc (25～50 mg/d) on 78 patients in order to control the systolic pressure under 140 mmHg. We observed the bun, cr and BP. The data were analyzed by T examination.Results With single plendil the efficacy of BP control rate was 80.77%(63/78), combined with betaloc together the rate was 94.87% (74/78). There was no significant difference in bun, cr before and after medication ( P>0.05 ). Conclusions There is an ideal efficacy of BP control in systolic hypertension with treatment of single plendil. It is better to combine with betaloc in the therapy, which have slight side effect and no adverse effect of renal function.
出处
《岭南心血管病杂志》
2003年第2期113-114,共2页
South China Journal of Cardiovascular Diseases
