摘要
对154例肝病患者(慢性活动性肝炎62例,早晚期肝硬化72例,肝癌20例)血清中Cu,Zn,Cd,Mn,Cu/Zn,Cd/Zn和常用肝功指标的相关性进行了研究。结果表明,慢性活动性肝炎和早期肝硬化血清铜低于对照组,随病情发展,晚期肝硬化、肝癌患者血清铜显著升高;除肝癌患者外,血清锌随病情发展递减下降,而肝癌患者血清锌突然升高,肝炎和肝癌组的血清镉显著高于对照组,血清锰除慢性活动性肝炎与对照组无差异外,肝硬化、肝癌组显著低于对照组。逐步回归分析揭示,Cu,Cd,AKP三因素与肝硬化演变为肝癌有重要关系;逐步判别分析选出Cu,GPT,ZnTT,γ-GT四个指标建立了慢性活动性肝炎、各期肝硬化及肝癌的判别方程。本项研究为微量元素、肝功能和各种肝病的关系及为诊断、鉴别诊断提供了依据。
In order to find out the relationship between different typesof liver diseases and trace elements in serum,154 patients with liverdisease(62 with chronic active hepatitis,72 with post hepatitic cirrhosis,and 20 with liver cancer)were studied。The results showed that bothchronic active hepatitis and early stage cirrhosis cases have lower serumlevel of copper.However,an increase was found with the process fromlate stage cirrhosis to liver cancer.There was a negative correlation bet-ween the serum level of zinc and the progress of viral hepatitis,but thecases with liver cancer had a significant increase of zinc.Comparingwith controls,the patients with viral hepatitis and liver cancer hadhigher levels of cadmium,but the cases with cirrhosis and liver cancerhad lower levels of manganese.The stepwise regression analysis(α=0.05)indicated that Cu,Cd,and AKP were associated with the process fromcirrhosis to liver cancer.A group of discrimination function equationswere established with stepwise discrimination analysis.The four factors,Cu,GPT,ZNTT,γ-GT,were significant in the equations.The resultsprovided some useful information for further study on trace elementsand liver diseases.
出处
《山东医科大学学报》
1989年第1期20-26,共7页
Acta Academiae Medicinae Shandong
关键词
微量元素
病毒性肝炎
相关性
Trace elements
Hepatitis,viral,human
Associated research
