摘要
实验证明大蒜提取液对人羊膜FL细胞株的细胞增殖有抑制作用,其作用环节在细胞周期的G_2/M期;适当浓度的大蒜提取液对促癌剂12-0-十四酰基-佛波醇-13-乙酸酯(TPA)诱发的蛋白激酶-C(PK-C)活性变化有拮抗作用,但大蒜提取液在较高浓度时本身能引起类似于TPA诱发的PK-C活性变化。
The possible mechanism of tumor promotion inhibiting activity of garlicextract was studied. The garlic extract could inhibit the cell proliferation of human amnionFL cell in vitro, exerting no influence on the S phase DNA synthesis while exhibitingobvious inhibitory effect on the mitosis of the cells. At suitable concentration, garlic ex-tract could also inhibit the changes of protein kinase C activity induced by tumor promoterTPA, while at higher concentration garlic extract itself could induce changes of proteinkinase C activity mimic to TPA stimulation.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
1993年第2期268-271,共4页
Chinese Journal of Pathophysiology
基金
国家自然科学基金
