摘要
目的 研究乙肝免疫球蛋白 (HBIG)联合乙肝疫苗阻断乙型肝炎病毒 (HBV)母婴传播的长期效果。方法 6 2 4例乙型肝炎病毒表面抗原 (HBsAg)携带者母亲的婴儿随机分组 ,按 0、1、6月龄单用乙肝疫苗 2 0 μg或出生时注射HBIG 10 0IU ,然后于 1、2、7月龄接种乙肝疫苗 2 0 μg。静脉采血随访HBsAg ,平均 (6 34± 1 71)年。结果 同单用疫苗比较 ,HBIG联合免疫使 1岁时慢性HBV感染率由 17 6 %降为 5 0 % ;总慢性HBV感染率双阳性组由 2 4 5 %降至 10 6 % (P <0 0 0 5 ) ,单阳性组由 10 7%降至 3 8% (P <0 0 2 5 )。双阳性组初现HBsAg阳性婴儿慢性化率也降低 ,在出生时HBsAg阴性而 1～ 6个月时出现HBsAg阳性婴儿 ,慢性化率由 40 9%降至 0 (P <0 0 5 ) ,出生时HBsAg阳性婴儿 1月龄HBsAg阴转率由 2 6 4%提高至 5 8 8% (P <0 0 5 )。结论 HBIG联合乙肝疫苗明显提高母婴传播阻断效果 ,减少慢性HBV感染率。
Objective To investigate the long-term efficacy of hepatitis B immunoglobulin(HBIG) combining with hepatitis B vaccine(HBvac) in interrupting the maternal-infantile transmission of hepatitis B virus.Methods 624 infants,whose mother were hepatitis B surface antigen(HBsAg) carrier,were divided into 2 groups randomly.HBvac 20mg was given at 0,1,6 month in group 1,while at 1,2,7 month combining HBIG 100IU at birth in group 2.Serum HBsAg was followed up for (6 34±1 71)year.Results The chronicity HBV infection in group 2 decreased from 17 6% to 5 0% compared to group 1 in 1 year.The incidance of chronic HBV infection in HBeAg positive mother' group decreased from 24 40% to 10 58%(P<0 05),10 66% to 3 82% in HBeAg negtive group(P<0 025).The chronicity of HBsAg in children with HBsAg positive at birth decreased.And the incidence of chronic HBsAg infection decreased from 40 9% to 0 in children getting HBsAg infection at 1～6 months after birth(P<0 025).Conclusion Combing therapy of HBIG and HBvac may interrupt maternal-infantile transmission and decrease the chronic HBsAg infection,the mechanism of which is the decrease of the chronic HBsAg infection tendency in infants.
出处
《中国实用儿科杂志》
CSCD
北大核心
2000年第9期558-560,共3页
Chinese Journal of Practical Pediatrics
基金
卫生部临床重点学科建设项目资助! (项目编号 :970 30 2 2 3)
