摘要
微量元素钒(Vanadium,V)有多种氧化价态.不同的钒化合物.其生物活性不同.我们比较了Na-VO_3与VOSO_4的降血糖作用.前者稍强.但VOSO_4的毒性较低.VOSO_4虽不影响正常动物的血糖.但可显著降低高血糖动物的血糖,其降血糖机制与胰岛素类似.
Vanadium (V) is one of the trace elements It exists in many oxidation states which exhibit different biological activities. Our results in alloxan diabetic mice suggest that NaVO3 and VOSO4 can decrease blood glucose level. The hy-poglycemic effest of VOSO4 was found to be weaker than that of NaVO3, the toxicity of
VOSO4 is also lower. However VOSO4; showed no effect in normal mice. The mechanism of the hypoglycemic effect of VOSO4 appears to be similar to that of insulin.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1993年第3期183-186,共4页
Chinese Pharmacological Bulletin
关键词
VANADIUM
钒
糖尿病
vandium
hyperglycemia
glycogcncis
glyconeogenesis
VOSO_4
