摘要
本文观察了芍药甙对Ｎａ，Ｋ－ＡＴＰａｓｅ及ＡＣ（腺苷酸环化酶）活性的影响，发现在反应体系中药物浓度为１０＾－７到１０＾－２ｍｏｌ／Ｌ之间的情况下，Ｎａ，Ｋ－ＡＴＰａｓｅ活恬随该成分浓度高而下降，当浓度为１ｍｍｏｌ／Ｌ时，抑制率为３１．６％；而浓度在４ｍｍｏｌ／Ｌ时抑制率达６１．６％；而ＡＣ则受到轻微的激活作用，在４ｍｏｌ／Ｌ浓度时加药组与对照组相比，酶活性提高了１４．１％（Ｐ＜０．０１）。
Paeoniflorin, an important component ex-tracted from the roots of the Chinese herbalmedicine Paeonia lactiflora, has been shownexperimentally to have the inhibitive action onthe Na, K-ATPase of rabbit's erythrocyteghosts. It can activate the activity of adenosincyclase. Matrine and Oxymatrine, two otherextracts from Sophora flavescens Ait. whichis widely used in Chinese medicine as 'cold-natured medicine', have been proved experi-mentally to have the inhibitive action on Na,K-ATPase. These results may help to explainthe mechanisms of these herbal medicines.
出处
《中国药学杂志》
CAS
CSCD
北大核心
1993年第11期658-660,共3页
Chinese Pharmaceutical Journal
关键词
芍药甙
皂甙
苦参
膜酶
paeoniflorin
matrine
Na
KAPTase
