摘要
本研究使用氘代川芎嗪(TMPz)为示踪剂,结合稳定同位素和GC/MS分析的离子簇技术,发现接受灌胃给予TMPz后大鼠的24h尿中存在有TMPz本身及其三种代谢产物.
The metabolism of tetramethylpyrazine (TMPz) in rats was investigated. Deuterated TMPz and unlabelled TMPz were administered by intragastric per-fusion to two rats, respectively. Extracts from urine samples were analyzed within 24h by gas chromatography/mass spectrometry (GC/MS). By applying the ion cluster technique, TMPz and its three metabolites were identified.
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
1993年第2期79-82,共4页
Acta Academiae Medicinae Sinicae
基金
国家自然科学基金
卫生部科研基金资助
关键词
川芎嗪
同位素
离子簇技术
代谢
tetramethylpyrazine (TMPz) stable isotope gas chromatograph-y/mass spectrometry GC/MS metabolites ion cluster technique
