摘要
本文对40例晚期胃癌应用3个化疗方案的疗效进行了评价。FMV、FMA和FM-UFT方案的有效率分别为50％、40％和50％,3个方案的疗效之间无差异,中数生存期为5个月。根治术后复发病人有效率(67％)较未手术者有效率(40％)明显为高(P<0.05)。副作用主要为恶心、呕吐、白细胞和血小板下降。但无因副作用而终止治疗者。
Three combination chemotherapy regimens FMV (5-fluorouracil, mitomycin C and vincristin ), FMA (5-fluorouracil,mitomycin C and adriamycin)and FM-UFT(5-fluorouracil, mitomycin C and UFT ), were used in 40 patients with histologically proven advanced gastric carcinoma in a prospective randomized trial. The response rates(CR +PR)with FMV,FMA and FM-UFT were 50%, 40% and 50% respectively. There was no significant difference in the response rates of the three regimens and the median survival period was five months.The response rate in petients who relapsed after radical operations was significantly higher than that in patients who had no radical operation (67% vs 41%,P<0. 05). The main side effects were nausea and vomiting, leucopenia and thrombocytopenia. No discontinuation of the treatments happened because of side effects.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
1993年第6期448-450,共3页
Chinese Journal of Clinical Oncology
关键词
胃肿瘤
药物疗法
Advanced gastric cancer
Combination chemotherapy
