摘要
由猕猴桃根提取制备而成的消星障滴眼液,在组织培养中对Ⅰ型单纯疱疹病毒有明显抑制作用,对实验性兔单纯疱疹病毒性角膜炎的疗效优于疱疹净滴眼液。长期滴眼无毒副作用。
The new guttae ophthalmic Xiaoxingzhang (XXZ)was extracted from Radix Actinidiae, a traditional Chinese herbal drug. The 50% inhibition concentration (IC_(50)) of XXZ on type Ⅰ Herpes Simplex Virus (HSV-1) in virus cell cultures is 165.48～174.73μg/ml. However, XXZ concentrations greater than 400μg/ml did not cause any microscopically visible disruption of veto cells. The efficacy of XXZ in the treatment of experimental Herpes Simplex Keratitis (HSK) in rabbits is higher than that of idoxuridine. The effective doses of XXZ are not toxic to corneal epithelium. The results suggest that XXZ as a new anti-HSV preparation is potentialy useful in the treatment of patients with HSK.
出处
《中国中药杂志》
CAS
CSCD
北大核心
1993年第1期49-52,共4页
China Journal of Chinese Materia Medica
基金
国家中医药管理局资助课题
关键词
消星障滴眼液
角膜炎
单纯疱疹病毒
Xiaoxingzhang Guttae Ophthalmic
Herpes Simplex Keratitis
Herpes Simplex Virus
