摘要
本实验通过切除 SD 雌性大鼠40只双侧卵巢并拔除全部磨牙后,用光镜、扫描电子显微镜(SEM)动态地观察失牙后1～8月剩余牙槽骨和股骨的组织学变化。结果表明:1.实验组剩余牙槽骨在失牙后早期(1月),组织学改变主要是骨小梁较细,骨髓腔较大,成骨细胞较少,呈梭形,未见破骨细胞,足以成骨障碍为主的骨量丧失;失牙后期(3～8月),突出的组织学改变是骨小梁明显减少,骨小梁边缘大量破骨细胞,致骨边缘呈蚕噬状,有散在孤立的小骨碎片;同时成骨细胞较少呈梭形。SEM的主要改变是骨小梁内矿化带排列紊乱,稀疏,出现间隙,因而是以骨吸收增加为主,同时伴有成骨障碍的骨量丧失。2.股骨在失牙后各程期中均主要为成骨障碍性骨量丧失。
After ovariectomy and extraction all molars in 40 rats,the observations of light microscopy and scanning elec-tron microscopy(SEM)were performed.Results showed:1)At early stage(1 month after operation),the bonetrabeculae were thinned,marrow cavities were enlarged,a few of osteoblasts and no osteoclast was found.There-fore,the decrease of bone volume was mainly due to the osteogenie disturbance.At late stage(3—8 monthes afteroperation),the bone trabeculae were marked decreased,there were large amount of osteoclasts.Under SEM,themain change of bone trabecula was disorderly,scattered and presented spaces in zone of mineralization.Therefore,the change was mainly due to bone absoption and associated with osteogenie disturbance.2)The bone loss of fe-mur was due to osteogenic disturbance in both two stages.
出处
《华西口腔医学杂志》
CAS
CSCD
北大核心
1993年第3期185-187,T011,共4页
West China Journal of Stomatology
