摘要
本研究用兔侧脑室给药观察了促甲状腺素释放激素（ＴＲＨ）对β－内啡肽心血管抑制作用的影响。结果表示，β－内啡肽（１０μｇ，ｉｃｖ）能显著抑制兔心血管功能，表现为血压下降，心机收缩力指标如左室收缩压（ＬＶＳＰ），心室内压最大上升和下降速率（±ｄｐ／ｄｔｍａｘ），心肌纤维收缩速度（Ｖｃｅ４０，Ｖｐｍ）和心肌收缩向量环面积（Ｌｐ）明显降低。β－内啡肽的这一作用可被ＴＲＨ（５０μｇ，ｉｃｖ）取消，阿片受体拮抗剂纳洛酮（ＮＡＬ，５０μｇ，ｉｃｖ）也可拮抗β－内啡肽的心血管抑制作用，表明，ＴＲＨ与内源性阿片肽系统有密切关系，结合以前的实验结果提示ＴＲＨ拮抗β－内啡肽的心血管抑制作用有可能是作用在阿片受体上的。
The effects of thyrotropin-releasing hormone(TRH)after intracerebroventricular administration(icv)on the inhibition of beta-endophin on the cardiovascular system were observed in rabbits,It was found that l0μg icv beta-endophin could result in a marked decrease of LVSP,±dn/dtmax,Vce 40,Vpm and Lo,The effects of beta-endophin could be abolished with 60μg of TRH or naloxone(50μg icv),an opioid antagonist.These findings suggest that there is a close relationship between TRH and the endogenous opioid system and the reversal effects of TRH on beta-endophin may be mediated through the opioid receptors.Whether TRH could directly act on opioid receptors await further investigation.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
1994年第6期402-404,共3页
Journal of Third Military Medical University
基金
国家自然科学基金
关键词
内啡肽
纳洛酮
血液动力学
TRH
thyrotropin releasing hormone
endophins
naloxone
hemodynamics
rabbits
