摘要
应用光谱法研究了手性金属配合物［Ｆｅ（ｐｈｅｎ）＿３］￣（２＋）与小牛胸腺ＤＮＡ的作用，确定了△型异构体对Ｂ型右手螺旋ＤＮＡ有优先键合的立体选择性．
The chiral complexes tris (phenanthroline) iron (Ⅱ) were synthesized. The structures of the complexes were determined by IR, UV, EXAFS, CD. The binding of the complexes to calf thymus DNA was studied by spectral methods. Hypochromism and enhancement of luminescence accompany DNA binding and the binding show the characteristic of intercalation. The enhancement of luminescence seen for △ isomer in the presence of DNA is greater than that for ∧ isomer. The luminescence quenchng produced by [Fe(CN)_6]￣(4-) for △ isomer in the presence of DNA is smaller than that for A isomer. It means that △isomer binds preferentially to B-DNA.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
1994年第12期1742-1745,共4页
Chemical Journal of Chinese Universities
关键词
铁络合物
DNA
立体选择性
Chiral metal complex, DNA, Stereoselectivity
