摘要
雄性ＳＤ大鼠饮用含苯巴比妥钠（１ｍｇ／ｍｌ）的饮水１周后，随机分为四组，每组８例：ＮＣ，２１％Ｏ＿２／７９％Ｎ＿２；ＨＣ，１４％Ｏ＿２／８６％Ｎ＿２；ＨＳ，１４％Ｏ＿２／８６％Ｎ＿２／１．２ＭＡＣ七氟醚；ＨＨ，１４％Ｏ＿２／８６％Ｎ＿２／１．２ＭＡＣ氟烷。吸入时间为１ｈ。２４ｈ后用原子吸收分光光度法测定血浆及肝匀浆中锌、铜、铁、钙的含量。结果ＨＨ组肝匀浆中铜、锌的含量显著低于对照组（Ｐ＜０．０１），钙离子显著高于对照组（Ｐ＜０．０１），ＨＨ组血浆中铁、铜、锌含量均显著高于对照组（Ｐ＜０．０５）。提示氟烷肝损害过程中铜、铁、锌由损伤肝组织向血浆中释放，这种释放程度与肝损害程度相平行。而且体内微量元素平衡的改变又会加重氟烷性肝损害的发生与发展。
ale Sprague-Dawley rats were pretreated with phenobaraital and randomly divided into 4 groups. The ratswere exposed to O2/N2/1.2 MAC anesthetics for 1 hr : 21%O2/79%N2(NC); 14%O2/86%N2(HC); 14%O2/86%N2/1. 2 MAC sevoflurane(HS) and 14%O2/86%N2/1. 2MAC halothane(HH)respectively. The rats givenhalothane had significantiy lower hepatic Cu2+, Zn2+ values and higher hepatic Ca2+ values(P<0. 01 ). Plasmacontents of Fe2+”,Cu”, Zn”were significantly raised in group HH (P<0.05). The results suggest that trace ele-ments are released from the liver to blood during halothane-related liver injury and the imbalance of trace elementsmay enhance halothane hepatitis.
出处
《临床麻醉学杂志》
CAS
CSCD
北大核心
1994年第2期64-66,共3页
Journal of Clinical Anesthesiology
关键词
麻醉药
肝毒性
微量元素
Volatile anesthetics Hepatotoxicity Trace elements
