摘要
目的 了解骨髓增生异常综合征 (MDS)的细胞表面标记与转化为白血病的相关性。方法 采用免疫荧光法检测 6 4例MDS患者的骨髓细胞 ,计算阳性细胞百分率 ,正常对照上限为阳性 ,并进行了相关的随访。结果 HLA -DR >2 0 %的MDS患者中 ,6 7%的患者转化为白血病 ,说明HLA -DR阳性与白血病的转化存在的相关性 ,分析其原因 ,可能是 :MDS病因可能是由于造血祖细胞病变所致 ,而HLA -DR在正常情况下也表达于造血祖细胞上。结论 高HLA -DR表达与白血病的转化存在一些相关性。
Objective To study correlation between immunolabelling of bone marrow cells and development to leukemia in myelodysplastic syndrome (MDS). Methods 64 cases of MDS were measured by immunofluorescence and positive cells were counted. Results 67% MDS patients with HLA-DR>20% developed leukemia eventually. The results showed HLA-DR positive was related with the development to leukemia. Conclusion High HLA-DR expression is related with the development to leukemia.
出处
《医师进修杂志》
2005年第3期18-19,共2页
Journal of Postgraduates of Medicine
