摘要
目的 研究阿司匹林 (ASA)预防缺血性卒中的疗效和最佳剂量。方法 10 0 0例缺血性脑血管病人随机分为ASAⅠ组 (5 0mg/d ,3 0 2例 )、ASAⅡ组 (3 0 0mg/d ,2 11例 )、ASAⅢ组 (10 0 0mg/d ,2 3 2例 )和对照组 (2 5 5例 ) ,随访2 4～ 60 (平均 3 0 .5 )个月。结果 ASA组卒中发生率 (平均 10 .9% )明显低于对照组 (19.6% ) (P <0 .0 1) ;ASA组病死率(平均 2 .5 % )低于对照组 (7.9% ) (P <0 .0 1) ;ASA组卒中与死亡危险性较对照组降低 3 9% [相对危险性 (RR )为 0 .62 ,95 %可信区间为 0 .45 0～ 0 .86] ;ASA组不良反应发生率为 3 4.8%。结论 ASA能降低缺血性卒中和死亡发生率 ,且最佳剂量为 5 0mg/d。
Objective To study the curative effect of aspirin ischaemic cerebrovscular disease and the best dose.Methods 1000 pateints with ischaemic cerebrovascular disease entered this multicenter,randomized study:302 were randomly assigned to aspirin 1 group(50 mg/d),211 to aspirin 2 group (300 mg/d),232 to aspirin 3 group(1 000 mg/d), and 255 to controlled group.The follow-up period was 24～60 (average 30.5) months.Results The rate of stroke in aspirin group (average 10.9%) was lower than that in controlled group(19.6%) (P<0.01). The rate of death in aspirin group (average 2.5%) was lower than that in controlled group (7.9%) (P<0.01). Cornpared with controlled group, aspirin groups showed a reduction of 39% (average) in the risk of stroke and death (relativer risk 0.62,95% confidence interval 0.45～0.86). The rate of adverse drug effects in aspirin group was 23.4%.Conclusion Aspirin can reduce the rate of stroke and death, and the best dose was 50 mg/d.
出处
《安徽医学》
2005年第2期96-98,共3页
Anhui Medical Journal
