摘要
目的:观察益气活血化痰法治疗老年高脂血症的临床疗效及对血管内皮功能和凝血系统的影响。方法:将96例老年高脂血症患者随机分为治疗组和对照组。治疗组56例,口服丹参决明颗粒,对照组40例,口服血脂康胶囊。观察指标包括血脂、血管内皮功能、凝血系统及安全性检测。结果:治疗后在降低血浆总胆固醇(TC)和低密度脂蛋白胆固醇(LDL-C)方面治疗组优于对照组(P<0.05)。血栓素 B_2(TXB_2)/6-酮-前列腺素 F_(1α)(6-keto-PGF_(1α))比值治疗后治疗组与对照组比较差异有显著性(P<0.05)。D-2聚体(D-D)、纤维蛋白原(FIB)两组治疗后比较差异有显著性(P<0.05)。结论:丹参决明颗粒具有调节老年高脂血症血脂代谢,改善血管内皮功能和凝血系统的作用。
Objective:To observe clinical therapeutic effects of method for supplementing Qi,activating blood circulation and resolving phlegm and effects on vascular endothelial function and blood coagulation system in senile patient of hyperlipemia.Methods:96 senile patients of hyperlipemia were randomly divided into a treatment group(n=56)and a control group(n=40).The patients of the treatment group were treated by oral administration of Danshen Jueming Granules and the control group by oral administration of Xuezhikang Capsules.Blood lipids,vascular endothelial function,blood coagulation system and safety were observed.Results:After treatment,the treatment group in decrease of plasma total cholesterol(TC)and low density lipoprotein-cholesterol(LDL-C)was superior to the control group(P<0.05).There was significant difference between the treatment group and the control group after treatment in TXB_2/6-keto-PGF_(1α)ratio,and there were significant differences between the two groups after treatment in D-dimer and fihrinogen(P<0.05).Conclusion:Danshen Jueming Granules has functions of regulating metabolism of blood lipids, improving vascular endothelial functions and blood coagulation system in the senile patient of hyperlipemia.
出处
《中医杂志》
CSCD
北大核心
2005年第2期107-109,共3页
Journal of Traditional Chinese Medicine
关键词
益气活血化痰法
高脂血症
血管内皮功能
凝血系统
中医药疗法
Hyperlipemia/TCM therapy
Hyperlipemia/blood
@Method for supplementing Qi,activating blood circulation and resolving phlegm
