摘要
目的制备治疗白癜风的补骨脂素脂质体凝胶,对其体外释药模式进行定量考察。方法以同浓度的补骨脂素凝胶为对照,用透析法检测补骨脂素脂质体凝胶的体外释药模式,并对其在 4℃下贮存 3周的释药稳定性进行研究。结果与补骨脂素凝胶比较,补骨脂素脂质体凝胶具有明显的缓释及长效作用,且前 3h释药符合Higuchi扩散模式 (k=4. 67%h-1 /2 ), 3h后遵循零级释药模式(k=0. 74%h-1 )。而补骨脂素凝胶在实验的 24h内释药均符合Higuchi扩散模式(k=7. 18%h-1 /2 )。在贮存期内,补骨脂素脂质体凝胶的释药模式及包封率均维持稳定。结论补骨脂素脂质体凝胶体外释药具有明显的缓释特征,稳定性理想,值得进一步研发。
Objective To prepare the liposome-encapsulated psoralen and evaluate its drug release properties in vitro. Methods The drug release profiles of liposome-encapsulated psoralen were evaluated by dialyzation using psoralen gel as the control. Changes of liposome-encapsulated psoralen and release rate were detected during a 3-week storage at 4 ℃ for evaluating the stability of the liposomal formulation. Results Compared with psoralen gel,psoralen-liposome gel showed prolonged-release properties and the release profile followed Higuchi diffusion model (rate constant k=4.67% h -1/2 ) in the first 3 hours and zero-order kinetics after 3 hours(k=0.74% h -1 ). Psoralen gel followed Higuchi diffusion model in the first 24 hours(k=7.18%h -1/2 ). The drug release model and entrapment efficiency of liposome-encapsulated psoralen remained stable during the 3-week storage at 4 ℃. Conclusion Liposomal gel might be a promising sustained release system for clinical application.
出处
《广东药学院学报》
CAS
2005年第1期24-25,29,共3页
Academic Journal of Guangdong College of Pharmacy
关键词
补骨脂
脂质体凝胶
体外释药动力学
psoralen
liposomal gel
drug release profiles, in vitro
