摘要
应用组织化学并结合光镜,对人参抑制二乙基亚硝胺(DEN)诱发大白鼠肝癌的动态研究表明:人参对DEN大白鼠肝癌发生发展有显著的抑制作用。早、中期阶段,实验组鼠肝细胞变性坏死及肝硬变比对照组显著减轻;晚期对照组肝癌发生率达100％,实验组仅为14.3％,两组间的差异有显著性意义。组织化学显示,各期实验组的DNA、RNA和糖原的含量及γ-谷氨酰转肽酶,琥珀酸脱氢酶和5'-核苷酸酶的活性均保持在相对正常的水平,对照组则异常地降低或增高。说明人参能够抑制DEN所引起的肝细胞损害,使DEN肝癌发生率明显降低。
The results obtained in our experimental studies indicated that there was definite inhibition in the development and growth of liver cancer in the groups of rats fed with ginseng and DEN The difference between the control and experimental groups is statistically significant (P<0.001). According to our experimental results, ginseng seems to play a role of protecting the hepatocells from injury by DEN. The degeneration and necrosis of the hepatocells in experimental groups were milder than those in the control ones. Histochemical studies also revealed that ginseng could protect the activities of SDH and 5'-NT and maintain the activity of r-GT and contents of DNA, RNA and glycogen at relatively normal levels. All these are contributory factors in reducing the incidence of DEN induced liver cancer.
出处
《同济医科大学学报》
CAS
CSCD
北大核心
1989年第5期343-346,共4页
Acta Universitatis Medicinae Tongji
关键词
人参
二乙基亚硝胺
肝癌
组织化学
ginseng
diethylnitrosamine
liver neoplasms
histocytochflristry
