摘要
Gene delivery systems are one of key issues that limit the development of gene therapy. The novel non-viral gene delivery systems fabricated via supramolecular assem- bly have begun to show increasing promising and applica- tions in gene therapy due to its suitable nanometric size, controllable structure and excellent biocompatibility. In this review, the fundamental and recent progress of non-viral gene supramolecular assembly is reviewed. Artificial vi- ruses——the future direction of non-viral gene delivery sys- tems are also described.
Gene delivery systems are one of key issues that limit the development ofgene therapy. The novel non-viral gene delivery systems fabricated via supramolecular assembly havebegun to show increasing promising and applications in gene therapy due to its suitable nanometricsize, controllable structure and excellent biocompatibility. In this review, the fundamental andrecent progress of non-viral gene supramolecular assembly is reviewed. Artificial viruses -thefuture direction of non-viral gene delivery systems are also described.
基金
This work was fnancially supported by the Natu—ral Science Foundation of Zhejiang Province(Grant No.M503151)
the National Natural Science Foundation of China(Grant No 50403021).
