摘要
目的 研究静脉滴注人血免疫球蛋白 (IVIG)对病毒性心肌炎 (VM)小鼠心肌细胞凋亡与坏死的影响。方法 将 32 0只Balb/c小鼠随机分为 8组 ,治疗组分别在接种病毒后不同时间予以不同疗程的IVIG治疗 ,并与黄芪治疗作对比。测定心肌病毒滴度、心肌细胞凋亡率和坏死率 ,计算心肌病理组织学积分。结果 各IVIG治疗组上述 3项指标均明显低于病毒对照组(P均 <0 .0 5)和黄芪治疗组 (P均 <0 .0 1 ) ,以早期长程治疗组最低。结论 IVIG能降低VM小鼠心肌细胞凋亡率、坏死率及心肌病毒滴度 ,疗效优于黄芪。
Objective To investigate the effects of intravenous immunoglobulin(IVIG) on apoptosis and necrosis of myocytes in mice with viral myocarditis.Methods Three hundreds and twenty Balb/c mice were randomly divided into 8 groups.Different courses of IVIG were given in varying time after virus inoculation,Chinese medicine Huangqi given in control group.The virus titer in myocardium、percentage of apoptosis and necrosis of myocytes were detected, myocardial histopathologic scores were counted.Results In every IVIG treatment group,the above 3 items were all significantly lower than that in virus control group and Huangqi group,as IVIG early long course group had the best effect.Conclusion IVIG may reduce the percentage of apoptosis and necrosis of myocytes and virus titer in myocardium in mice with viral myocarditis,the effects are better than that of Huangqi.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2005年第3期233-235,共3页
Journal of Applied Clinical Pediatrics
