摘要
目的:探讨周围型小肺癌的MRI征象与其病理标本P53蛋白的相关性。材料和方法:从42例行MRI检查肺癌病例中选择直径≤3.0cm的小肺癌26例为研究对象(男15例,女11例),腺癌18例,鳞癌7例,鳞腺癌1例。均常规行MRI检查,设备为GESigna或SignaMR?i1.5TMRI扫描仪。18例ABC法行P53蛋白检测并与MRI征象对照。结果:出现分叶征20例,边缘毛糙23例,其中12例可见毛刺征,胸膜凹陷征6例,淋巴结转移12例;P53蛋白在肺腺癌和鳞癌组织中均为高表达,分别为66.7%和83.3%;肺癌分叶征及淋巴结转移的有无其P53阳性表达有显著差异(P<0.05),毛刺征及胸膜凹陷征的有无其P53阳性表达无显著差异。结论:周围型小肺癌的某些MRI征象与反映其生物学的P53蛋白具有相关性。
Objective To evaluate the relationship between MRI manifestations of peripheral small lung cancer and P53 expressions of its specimen. Materials and Methods Twenty-six patientsmale 15 and female 11 with small lung cancer≤3.0cm in diameter were chosen from 42 cases with lung cancer examined with MRI. There were 18 cases with lung adenocarcinoma 7 cases with squamous cell carcinoma and 1 with squamo-adenocacinoma. GE Signa and Signa MRi 1.5T MRI were used. P53 abnormal expression detected with ABC method and MRI manifestations were studied comparatively in 18 cases. Results There were lobulations in 20 cases poor-margins in 23 cases and 12 of them with spiculations pleural indentations in 6 cases and lymph node metastasis in 12 cases. High P53 expressions were found in both lung adenocarcinoma and squamous cell carcinoma with 66.7% and 83.3% respectively. The appearances of lung cancer with lobulations and lymph node metastasis were related to P53 abnormal expressionP<0.05 and the spiculations and pleural indentations signs were not related to P53 abnormal expressionP>0.05. Conclusion Some of the MRI manifestations of peripheral small lung cancer were related to the abnormal expression of P53 reflected the biological behavior of lung cancer.
出处
《中国临床医学影像杂志》
CAS
北大核心
2005年第3期137-140,共4页
Journal of China Clinic Medical Imaging
关键词
肺肿瘤
磁共振成像
lung neoplasms magnetic resonance imaging
