摘要
[目的]探讨米非司酮、米索前列醇配伍利凡诺羊膜腔内注射终止中期妊娠的临床效果、安全性.[方法]对120例中期妊娠(16～24周)要求终止妊娠的妇女,随机分成研究组和治疗组.研究组:61例米非司酮75 mg,每12 h重复1次,共服150 mg.同时羊膜腔内注射利凡诺100 mg,第2天晨阴道内置入米索前列醇400 μg,每12 h重复1次,最多3次.治疗组:59例羊膜腔内注射利凡诺100 mg,不加任何辅助方法,胎儿、胎盘娩出后,必要时行清宫术.[结果]两组流产成功率分别为98.36%和94.91%.研究组的成功率明显高于治疗组,两组间的差异有显著性意义(P＜0.05).两组引产总时间分别为(33.02±3.14) h和(41.19±5.14) h,两组间的差异有显著性意义(P＜0.05).胎儿娩出后2 h内出血量两组差异有显著性(P＜0.05).产后子宫出血持续时间和月经复潮时间,两组差异无显著性(P＞0.05).研究组有胃肠道反应,但无需处理.治疗组未发现明显副反应.[结论]口服米非司酮150 mg,合并阴道放置米索前列醇及羊膜腔内注射利凡诺,是较好的药物终止中期妊娠的方法,联合使用有很好的协同作用.
To study the clinical effectiveness、safety of mifepristone and misoprostol with rivanol intra-amniotic injection for the interruption of midtrimester pregnancy.One hundred and twenty women requesting induction of labor in midpregnancy (16~24 weeks)were divided into two groups randomly.Group A(61 caces)was given mifepristone 75mg stat. and after 12 hours ,150mg in total. In the meantime, intra-amniotic injection of rivanol 100 mg was done. Next morning, misoprostol 400 μg was put in the vaginal fornix, repeated after 12 hours,at most for three times. Group B(59 cases)was given rivanol 100mg by intra-amniotic injection without any auxiliary therapy. After fetus and placenta expulsion,curettage was done if necessary.Successful abortion rates in Group A and Group B were 98.36% and 94.91% respectively. Group A was significantly higher than group B(P<0.05).Total time of abortion in Group A and Group B was (33.02±3.14) hours and (41.19±5.14) hours respectively, there was significant difference between them(P<0.05). The amount of bleeding in two hours after placenta expulsion showwed significant difference between two Groups (P<0.05). There was no difference between two groups in time of postpartum hemorrhage and next menstruation(P>0.05).Group A had gastrointestinal reaction, but needn't manage.Group B had not any obvious side effect.[Conclusion]It's a better way to interrupt midtrimester pregnancy with mifetristone 150mg and misoprostol plus intra-amniotic injection rivanol. There is good synergism of combined treatment. It can be considered as a routine method to be recommended in clinic use widely.
出处
《医学临床研究》
CAS
2005年第3期332-334,共3页
Journal of Clinical Research
