摘要
目的 :了解烧伤患者的血清肌钙蛋白I(TnI)水平 ,以明确TnI测定对烧伤后心肌损伤诊断价值。方法 :采用双抗体夹心ELISA方法测定92例烧伤患者的血清TnI水平并与患者伤后血清心肌酶水平比较,同期与22例心肌梗死患者进行对照。结果 :TnI在特重度烧伤组为 (8.12±1.44)ng/ml,阳性率为50.0 % (10/20) ;重度烧伤组为 (3.62±0.99)ng/ml,阳性率为20.0 % (5/25) ;电击伤组为 (8.90±1.70)ng/ml,阳性率为48.0 % (12/25) ;心梗组为 (74.45±22.5 )ng/ml,阳性率为100.0% (22/22)。表明烧伤后血清TnI升高水平及阳性率与烧伤面积有关 ,且多数病人血清TnI水平在伤后48h内升高。结论 :烧伤患者早期即存在心肌损伤 ,测定血清TnI对于烧伤后心肌损伤诊断的特异性明显优于心肌酶。
Objective:To observe the level of troponin I(TnI)of burned patients for evaluating the diagnostic value of TnI in myocardial injury in burned patients.Methods:ELISA was adopted to detect serum TnI in92burned patients.The serum TnI levels were compared with the levels of serum myocardial enzymes.22cases of myocardial infarction were enrolled in control group.Results:The serum TnI levels of patients in extreme burned group,severe burned group,electric burned group and myocardial infarction group were(8.12±1.44)ng/ml,(3.62±0.99)ng/ml,(8.90±1.70)ng/ml,(74.45±22.5)ng/ml respectively.Their positive rates were50.0%,20.0%,48.0%and100.%respectively.It made clear that the serum TnI levels and positive rates were related to burn size,and most burned patients,the TnI levels inˉcreased in postburn48h.Conclusion:Burned patients had myocardial injury in early stage of burn.Specificity of serum TnI for diagnosing the myocardial injury is higher than the index of serum enzymes in burned patients.
出处
《天津医科大学学报》
2004年第4期544-546,共3页
Journal of Tianjin Medical University
