摘要
研究了用氯化L 肉碱腈水解制备L 肉碱盐酸盐的反应工艺 ,发现在较低反应温度 ,较长时间的条件下 ,可以避免脱水副反应 ,提高产物的产率和纯度。最佳反应条件为 :以浓盐酸为水解试剂 ,反应温度 60°C ,反应时间 8h。在此条件下 ,L 肉碱盐酸盐的产率为 65 .8% ,光学纯度为 99.2 %。
Preparation of L-cyrnitine hydrochloride from L-cyano-carnitine chloride was studied. It was found that the side reaction of dehydration could be avoided, and the yield and purity of product could be raised under the conditions of lower reaction temperature and longer reaction time. The optimum reaction conditions were: hydrolytic reagent was concentrated hydrochloric acid, reaction temperature was 60(°C), reaction time was 8 h. Under these conditions, the yield of L-carnitine hydrochloride was 65.8%, and the optical purity was 99.2%.
出处
《化学世界》
CAS
CSCD
北大核心
2005年第2期100-102,共3页
Chemical World
基金
江西省科技厅2000年攻关资助项目:赣科鉴字(2002)第140号.
关键词
氯化L-肉碱腈
L-肉碱盐酸盐
水解
L-肉碱
L-cyano-carnitine chloride
L-carnitine hydrochloride
hydrolytic decomposition
L-carnitine
