摘要
目的 :验证战伤喷剂在创伤早期抗感染的效果 ,以及战伤喷剂对战创伤感染发生的影响。方法 :采用烫伤合并人工感染绿脓杆菌的家兔模型 ,用战伤喷剂与溶剂组于实验前和实验后第 1、2、4、7、14天采集家兔血清 ,测量体温 ,检测白细胞数、血清NO2 -/NO3 -水平、血清肿瘤坏死因子水平、血清超氧阴离子等炎性因子水平以及谷丙转氨酶、碱性磷酸酶、天冬氨酸转移酶、肌苷和尿素氮等肝肾功能指标水平。结果 :实验组药效学检测指标的升高比对照组缓慢 ,最终 2组均达到较高的感染发生指标 ;器官功能的安全性指标无明显变化 ,且 2组变化大致相同。结论 :战伤喷剂在创伤早期应用可以有效延迟创伤感染的发生 ,但并不能阻止感染的发生或减轻感染的程度。
Objective: To demonstrate the effect of the combat trauma spray on anti-infection in the early stage of trauma, as well as infection occurrence following trauma. Methods: A rabbit model was developed with scald complicated with artificial infection of Pseudomonas aeruginosa. Studies were carried out by using the combat trauma spray group and the solution group. At day 1,2,4,7,14, post experiments, rabbit serum was collected, the body temperatures of animals were taken, and such inflammatory factors as white cell count, serum levels of NO 2 -/NO 3 -, serum levels of tumor necrosis factor, serum superoxide anion, as well as GPT, AKP, aspartate carbamyl transferase, urea nitrogen were also collected to measure the functions of both the kidney and liver. Results: The measured data of pharmacodynamics in the experimental group rose more slowly than that of the control group. However, the 2 groups all reached a rather high infection incidence. But in the safety data of organ functions, there were no significant changes, which were identical in both groups. Conclusion: The application of combat trauma spray in the early stage of trauma can effectively delay the occurrence of trauma infection, nevertheless, it can neither prevent infection nor alleviate the extent of infection.
出处
《海军医学杂志》
2005年第1期5-8,共4页
Journal of Navy Medicine
关键词
战伤喷剂
感染
炎性指标
药效学
烫伤
combat casualty spray
infection
inflammatory factor
pharmacodynamics
scald
