摘要
调节性T细胞是目前免疫学领域研究的热点,对于维持机体免疫耐受和免疫应答稳态具有非常重要的作用. 对其发育和功能机制的深入认识,不但有助于了解错综复杂的免疫系统理论,而且在自身免疫性疾病、肿瘤和艾滋病的治疗以及移植耐受的诱导等方面具有广泛的应用前景. 最近的研究发现,转录因子Foxp3对于调节性T细胞的发育具有重要的作用,是调节性T细胞发育的一个关键转录因子.
Regulatory T cells, which play an important role in the maintenance of the immune tolerance and immune homeostasis, have become a hot research field in immunology in recent years. Researching on the regulatory T cell is not only very important to realize the complex immune system, but also has the great potential application to the therapy of autoimmune diseases, cancer, HIV infection and transplantation. The recent experimental results have demonstrated that a transcription factor Foxp3 plays a critical role in the development of regulatory T cell and is a critical regulator for the development of regulatory T cells.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
2005年第2期106-110,共5页
Progress In Biochemistry and Biophysics
基金
中国科学院引进海外杰出人才/百人计划资助项目.~~
