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溶血磷脂酸对豚鼠心肌细胞电压依赖性钾离子通道电流的作用 被引量：6

Effects of lysophosphatidic acid on voltage dependent potassium current in myocytes of guinea pigs
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摘要 目的 :观察溶血磷脂酸 (L PA)对豚鼠心肌细胞电压依赖性钾离子通道电流的作用。方法 :用膜片钳实验技术记录胶原酶急性分离的豚鼠心室肌细胞钾通道电流。结果 :共记录了 33个心室肌细胞的电压依赖性外向K+通道电流发现 1.0 μm ol· L- 1和 10 .0 μmol· L- 1 L PA可明显降低 K+通道电流的幅值。结论 :L PA可能参与心肌梗塞时心律失常的发生。 Objective To observe the effects of lysophosphatidic acid (LPA) on voltage dependent potassium current in myocytes of guinea pig.Methods The whole cell patch clamp technique was used in isolated ventricular cells of guinea pigs. Results Thirty-three voltage dependent potassium current in myocytes were recorded. LPA (1.0 and 10.0 μmol·L~ -1) could significantly decrease the amplitude of the potassium current of ventricular myocytes. Conclusion LPA may participate in arrhythmia occurrence during myocardial infarction.
作者 李英骥 赵春燕 张文杰 李欣 卢静 李丽 钟国赣
机构地区 吉林大学基础医学院生理学教研室
出处 《吉林大学学报（医学版）》 CAS CSCD 北大核心 2005年第2期193-195,共3页 Journal of Jilin University：Medicine Edition
基金 吉林省自然科学基金资助课题 (30 370 5 72)
关键词 溶血磷脂酸 膜片钳技术 心室肌细胞 钾通道 lysophosphatidic acid patch clamp technique myocytes potassium channels
分类号 Q463 [生物学—生理学] R-332 [医药卫生]
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参考文献8

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二级参考文献5

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共引文献14

同被引文献33

  • 1鲁奇良.急性冠脉综合征患者血浆溶血磷脂酸水平观察[J].中外医疗,2008,27(19):51-52. 被引量：2
  • 2葛敬岩,赵春燕,张文杰,赵明,孙亚芹,钟国赣.1-磷酸鞘氨醇对豚鼠心室肌细胞钙电流的影响[J].吉林大学学报（医学版）,2005,31(1):52-54. 被引量：3
  • 3何兰杰,韩变梅,马睿,李虹伟,沈潞华,陈曦.溶血磷脂酸及其受体在大鼠心肌重塑中的作用[J].基础医学与临床,2005,25(7):615-619. 被引量：5
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吉林大学学报（医学版）
2005年 第2期

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