摘要
目的:深入探讨金铁锁水煎浸膏对实验性类风湿关节痛的镇痛作用,并阐述其作用机制。方法:在以弗氏完全佐剂(Freund'scompleteadjuvant,FCA)作为实验性类风湿性关节炎(rheumatoidarthritis,RA)疼痛模型基础上,采用金铁锁水煎浸膏(大、中、小剂量组),并设立空白对照组、模型组、中药阳性对照组和西药阳性对照组治疗,并检测其痛阈和脑组织神经递质的变化。结果:金铁锁水煎浸膏对实验性RA关节痛具有显著的镇痛效应,明显提高痛阈并显著提高大鼠脑中5-羟色胺(5-HT),5-羟吲哚乙酸(5-HIAA),5-羟色氨酸(5-HTP)的含量,降低多巴胺,去甲肾上腺素(NE)含量脑组织神经递质。结论:对研究金铁锁的镇痛机制及镇痛作用规律,具有理论和实际意义。
AIM:To further investigate the analgesic effect of jintiesuo(decocted extract) on experimental rheumatoid arthritis(RA) and expound its mechanism of action.METHODS:The model of RA induced pain in rats by using Freund's complete adjuvant(FCA).The rats treated with low,middle and high doses of jintiesuo were used in jintiesuo treatment groups,and meanwhile control group,model group,traditional Chinese medicine(TCM) positive control group and western medicine positive control group were set up.The changes of pain threshold and brain neurotransmitter of the rats in all the groups were detected.RESULTS:Jintiesuo had obvious analgesic effect on the joint pain induced by experimental RA.It could significantly increase pain threshold,remarkably elevate the level of 5 hydroxytryptamine(5 HT),5 Hydroxyindoleacetic acid(5 HIAA),5 Hydroxytryptophan(5 HTP) in rat brain tissues,decrease the level of dopamine(DA),norepinephrine(NE) and reduce the content of neurotransmitter in brain tissues.CONCLUSION:Our study has a theoretical and practical significance to research the analgesic mechanism and the analgesic regularity of jintiesuo.
出处
《中国临床康复》
CSCD
北大核心
2005年第10期96-97,共2页
Chinese Journal of Clinical Rehabilitation
基金
江苏省药用植物生物技术重点实验室(KJS02116)~~
