摘要
虽然流行性感冒(流感)病毒的自然宿主是野生水禽类,作为宠物的雀形目鸟(Passeriformes)不代表流感病毒主要储存库[1-4,6,7],但Stallknecht和Shane 1988年对21 318份鸟的样品分析后发现,雀形目鸟中流感病毒的分离率占2.9%,表明雀形目鸟在流感病毒储存库中起着一定的作用.
This study characterized the NA genes of five H3N8 caged pet bird influenza viruses from Hong Kong, Indonesia, New Jersey, Singapore and Belgium, respectively. Phylogenetic analysis showed that NA genes of H3N8 caged pet birds influenza viruses are all grouped together and highly related,with 95.9% -99.6% similarity to each other. Especially, the caged pet bird viruses from Hong Kong are more closely related, with 99.6% identity to each other. NA genes of caged pet bird viruses belong to North America lineage. The NA genes of caged pet bird viruses are highly related to A/Mallard/Edmonton/220/90(H3N8) ,with 95.9% -94.2% similarity. The homologies to the Euro-Asian lineage virus A/Duck/Hokkaido/8/80 (H3N8) are only 75.7% -76.4%. Amino acid analysis showed that all the N8 genes of North America influenza viruses, including the caged pet bird viruses in this study,have potential glycosylation(NGS)at 43 - 45 sites,while equine and Euro-A-sia avian influenza viruses have no potential glycosylation at these sites.The potential glycosylation at site 47 might correlate with host species.In general,the N8 genes of caged pet bird H3N8 viruses are molecular closely related to each other and to earlier isolates of H3N8 influenza viruses from different regions of the world indicating that NA genes of these viruses are highly genetically conserved and that a stable lineage occurs in passerine birds. All the NA genes of caged pet bird H3N8 influenza viruses came from a common precursor. Passeriformes plays an important role in transmission and maintenance.
出处
《病毒学报》
CAS
CSCD
北大核心
2005年第2期145-149,共5页
Chinese Journal of Virology
基金
National Institute of Allergy and Infectious Diseases Public Health Service Research Grants.Al95357
