摘要
目的 :观察羟基喜树碱 (HCPT ,拓僖 )联合顺铂 (DDP)治疗晚期鼻咽癌 (NPC)的近期疗效及不良反应。方法 :应用HP方案治疗晚期NPC 2 8例。HCPT(6mg/m2 d1～ 3 )加入NS 2 0mL缓慢滴注 ,DDP(2 5mg/m2 d1～ 3 )加入NS 5 0 0mL中滴注 ,每 3周重复 ,至少治疗 2个周期。结果 :本组完全缓解 3例 ,部分缓解 12例 ,稳定 10例 ,进展 3例 ,总有效率 5 3. 6 %。主要毒副反应为WBC减少、恶心呕吐、腹泻、脱发。其中Ⅲ～Ⅳ度WBC减少发生率 35 . 7% ,Ⅱ～Ⅲ度恶心、呕吐 4 2 . 9% ,腹泻2 5 . 0 % ,脱发 35. 7%。结论 :HCPT联合DDP治疗晚期NPC疗效好 ,且毒性可以耐受。
Objective: To evaluate the efficacy and adverse reactions of hydroxycamptothecin(HCPT)combined with cisplatin(DDP )in the treatment of advanced nasopharyngeal cancer(NPC). Methods: Twenty-eight patients with advanced NPC were injected HCPT(6 mg/m2 d 1～3 )with normal saline of 20 mL and DDP(25 mg/m2 d 1～3)wit h normal saline of 500 mL every 3 weeks.The treatment was repeated from 2 to 6 cyc les. Results: The total effective rate was 53.6% with complete remission of 3 c a ses and partial remission of 12 cases. Grade 3/4 leucopenia was occurre d in 32. 1% patients, grade 2/3 nausea and vomiting was 42.9%, diarrhea was 25.0%, al opecia was 35.7%. Conclusion: HCPT combined with DDP is a safe and effec tive method for advanced NPC.
出处
《汕头大学医学院学报》
2005年第1期27-28,共2页
Journal of Shantou University Medical College
