摘要
为探讨缺血性脑卒中患者ET、CGRP及血清MDA、SOD测定的意义, 用放射免疫分析法及 TBA比色法测定了患者血浆ET、CGRP及血清MDA、SOD水平。结果提示, 小面积梗死组和大面积梗死组 ET水平均显著高于正常对照组(P均小于 0.01)。两病理组之间比较均存在显著差异(P均小于 0.05)。大面积组 ET与CGRP呈显著负相关(r= 0.668,P<0.05)。MDA及SOD统计值的变化关系与 ET、CGRP基本一致。由此认为, 四项指标的变化与脑血管损伤程度关系密切, 其测定有助于判断病情。
To investigate the clinical significance of determination of ET, CGRP and MDA,SOD in patients with ischemic cerebral apoplexy, plasma ET, CGRP and serum MDA, SOD levels were determined with RIA and TBA.The results showed that ET levels in patients with small and large cerebral infarctions were significantly higher than those in controls(P<0.01), and the levels in patients with large lesions were significantly higher than those in patients with small lesions(P<0.05).In patients with large lesions, the ET level was significantly negatively correlated to the CGRP level.The patterns of change in levels of MDA and SOD were similar to those of ET and CGRP.The imbalance between the two systems was closely related to the severity of cerebrovascular injury.Therefore,determination of their concentrations could help to evaluate the severity of ischemic cerebral apoplexy and its prognosis.
出处
《标记免疫分析与临床》
CAS
2005年第1期7-9,共3页
Labeled Immunoassays and Clinical Medicine
