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台阶变温法预测聚乙烯吡咯烷酮碘溶液的贮存期

Forecast of shelflife of povidone-iodine solution by staircase non-isothermal method
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摘要 用台阶变温法预测了l00g/L聚乙烯吡咯烷酮碘溶液的贮存期.实验表明.有效碘含量变化的动力学方程为lgCo一lgC=Kt,由此可求出各恒温段的速度常数Ki,从而得回归议程lgK=11.566-4.866X103/T.在288K,有效碘初始含量(Co)为9.lg/L时,贮存期约为55.2d,这与经典恒温法预测的结果(56.7d)某本一致,并与留样观察结果相符. he shelflife of 100g/L povidonc-iodine solution was forcasted by staircase non-isother-mal method.The dynamical equation on the variance on the variance of content of the available iodine was lgCo ─lgC =Kt,the velocity constant Ki at everyisothcrmal staircase could be calculated form that and the regression equation obeained was lgK=11.566-4.866x103/T.The shelflife was about 55. 2days at 288K when the initial content of the available ionine (Co)was 9.lg/L and that was compatible with those of both the classical isothermal method and sample-keeping observation.
出处 《延边医学院学报》 CAS 1994年第2期135-137,共3页 Journal of Medical Science Yanbian University
关键词 消毒剂 PVP-I 稳定性 药物贮藏 povidone-iodine stability drug storage
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参考文献3

  • 1秦元满,朴龙洽,罗永善,黄行铁.聚乙烯吡咯烷酮碘贮存期预测[J].延边医学院学报,1992,15(2):121-123. 被引量:4
  • 2张书楣,俞景霞.新型消毒剂—聚乙烯吡咯烷酮碘(PVP—I)[J]浙江药学,1985(01).
  • 3庞贻慧,方积乾,侯新朴.台阶型变温加速试验——药物稳定性预测的新方法[J]药学学报,1981(01).

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