摘要
建立了人血清中双氯芬酸的反相高效液相色谱测定方法。该法操作简便、精密度好、方法回收率为９８．２～１０２．５％，日内、日间ＲＳＤ为１．２９～４。５２％，血药浓度在０．２～１０μｇ／ｍｌ范围内呈线性关系，相关系数０；９９９９，当信噪比为２时，最低检测限为１０ｎｇ／ｍｌ。健康志愿者口服１００ｍｇ双氯芬酸肠溶衣片，药代动力学过程符合一室开放模型，消除半衰期为２．１５ｈ。
A sensitive and rapid high- performance liquiu chromatographic method
has beendeveloped for the determination of dicfofenac in human serum.
The average recovery of diclofenacwas 98.2%to 102.5%.The relative
standard deviation was 1.29%to 4.52%.The calibrationcurve was linear
in the range from 0.2μg/ml to 10.0μg/ml with r= 0.9999.The
detection limit ofthe method was 1 0 ng/ml.The serum drug
concentration time curve exhibited a 1-compartmentopen model and the
mean T1/2 was 2.15 h.
出处
《药学学报》
CAS
CSCD
北大核心
1994年第3期228-231,共4页
Acta Pharmaceutica Sinica
