摘要
目的:观察吸入激素布地奈德和口服酮替芬加肌注斯奇康联合应用能否降低毛细支气管炎后哮喘的发生率。方法:将我院2 0 0 0年1月至2 0 0 2年1月诊治的95例毛细支气管炎患儿(简称毛支炎)随机分为防治组和观察组。两组在急性期都给予常规治疗。4 7例防治组患儿应用了吸入皮质激素布地奈德1 0 0 μg/次,每天2次,2个月后减至1 0 0 μg/次,每天1次,维持4个月后停用。口服酮替芬3个月,肌注斯奇康6个月。对照组4 8例急性期后不给与任何药物防治。结果:完成随访>2年者,防治组4 1例中有2例发生哮喘,发生率4 88% ,而对照组完成随访的4 4例中有1 6例发生哮喘,发生率3 6 3 6 % ,两组差异有显著性,P <0.0 0 1。毛支炎干预治疗后各项肺功能指标明显改善。与对照组相比差异有显著性,P <0 .0 1。结论:吸入布地奈德、口服酮替芬。
Objective:To investigate whether it can reduce the incidence of asthma after bronchiolitis treated by inhaling budesoninde combined with administering ketontifen orally and intramuscular injecting BCG-PSN.Methods:95 babies were admitted to our hospital from January,2000 to January,2004.All of them were treated routinely at emerging course. They were divided into two groups (47 in treated group and 48 in control group).47 babies in treated group were treated by inhaling budesoninde 100 μg/dose,twice per day for two months,followed by 100 μg/dose,once per day for 4 months.At the same time,these babies were administered ketontifen orally for 3 months and BCG-PSN injection for 6 months. The control group ceased therapy after routine treament at emerging course.All these 95 babies were followed up for two years.Results:The incidence of asthma was 4.88%(2/41) in treated group, but 36.36% (16/44) in control group as well. There was significant difference between the two groups(P<0.001).The pulmonary function in treated group was improved significantly after treament compared to control group( P<0.01).Conclusion:To the babies with bronchiolitis,it can reduce the incidence of asthma treated by inhaling budesoninde combined with administering ketontifen orally and injecting BCG-PSN.
出处
《现代预防医学》
CAS
北大核心
2005年第4期375-376,共2页
Modern Preventive Medicine
