摘要
目的观察百岁老人血小板活性和纤溶活性变化。方法21例百岁老人检测PAgT,TXB2,6酮-PGF1α,GMP-140,t-PA:Ag,PAI:A六项指标与30例健康老人对照探讨血小板活性和纤溶变化。另对9例百岁老人作了尸检。结果六项血小板活性和纤溶指标测定结果:其中百岁老人组与对照组有一定差异。9例百岁老人尸检,其中1例肺梗塞,1例膀胱下静脉栓塞,1例多发性局灶性心肌梗塞。结论百岁老人出现血小板活性增高,纤溶失调,临床需密切注意有无血栓形成和血栓性疾病发生。
Objective The change of platelet activity and plasminogen activity in centenarians was studied. Methods Twenty one centenarians were tested for PAgT, TXB2, 6 acetone-PGF1α, GMP-140, t-PA:Ag, PAI:A in compare with 30 healthy elders. The changes of platelet activity and plasminogen activity were investigated. Autopsy was performed on 9 deceased centenarians. Results Among the 6 parameters tested, the PAgT,TXB2, 6 acetone-PGF1α, GMP-140, t-PA:Ag,and PAI:A in centenarian group were statistically different from that in control group. In 9 centenarian autopsies, one showed pulmonary infarction, one with urinary bladder inferior vein embolism, and one with multiple local myocardial infarction. Conclusions If centenarian shows an increase of platelet activity and imbalance of plasminogen activity, the clinicians must pay attention to the possibility of thrombus formation and thrombotic diseases.
出处
《老年医学与保健》
CAS
2004年第3期142-143,153,共3页
Geriatrics & Health Care
基金
卫生部课题(编号:962278)
华东医院院级课题(编号:03-003)
