摘要
目的测定儿童口服复方氯胺酮的血药浓度并探讨血药浓度与药效学的关系。方法用高效液相方法测定用药后不同时点氯胺酮(KET)、咪达唑仑(MZ)、阿托品(AT)的血药浓度;观察药物显效时间、镇静止痛效果。结果KET的tmax=(30±15)min,Cmax=(633±121)ng·mL-1;MZ的tmax=(30±15)min,Cmax=(105±35)ng·mL-1。患儿服药(10±4)min,血中可测到KET、MZ的含量;(30±20)min达峰;未检测到AT。结论复方氯胺酮口服液起效时间与其血药浓度高峰期相近。
Objective To monitor the blood concentration of ketamine(KET), midazolam(MZ) and atropine(AT) in children after the administration of compound ketamine oral solution(CKOS) and discuss the correlation-ship of concentration pharmacodynamics. Methods The blood concentration of KET (5 mg·kg -1), MZ (0.5 mg·kg -1) and AT (0.03 mg·kg -1) were monitored by high-performance liquid chromatograph. The trigger time of effect, the sedation effect, and the state of emotion were all studied. Results KET and MZ can be detected 10 min after the drug administration, and t max is about 30 min. AT hasn' t been detected all the time. The observation of pharmacodynamics: the trigger time was (13±4) min, the peak of sedation time was (33±20) min. Conclusion The sedative and ease pain effect of CKOS are correlated with the drug blood concentration.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2005年第1期50-53,共4页
The Chinese Journal of Clinical Pharmacology
基金
辽宁省自然科学基金资助项目(20022074)
