摘要
自噬是真核细胞中广泛存在的降解/再循环系统. 自噬在氨基酸和激素的调控下对蛋白质等大分子和细胞器进行降解,降解产物可作为新合成蛋白质和细胞器的原料. 作为Ⅱ型程序性细胞死亡,自噬与凋亡相互作用,参与维持机体的自稳态,在生物体正常发育及对某些环境胁迫的响应极为关键. 对自噬在生物体发育、老化以及在肿瘤、神经退行性病变、肌病和抵御微生物侵染中的作用进行了综述.
Autophagy occurs in all types of eukaryotic cells, which has a rigid connection to normal development of cells and a variety of diseases. There are many molecular control elements and multiple signaling pathways involved in regulating autophagy. Autophagic cell death is considered as the type II programmed cell death. There is a crosstalk between autophagy and apoptosis. Both of them participate in maintaining cell homeostasis and pathogenesis of certain diseases. The roles of autophagy in development, aging, tumor, neurodegenerative diseases and infectious diseases are reviewed.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
2005年第4期298-303,共6页
Progress In Biochemistry and Biophysics
基金
国家自然科学基金资助项目(3037506)
苏州市社会发展基金资助项目(SRC-0304).~~
关键词
自噬
细胞代谢
老化
肿瘤
神经退行性病变
病原菌侵染
CHAPERONE-MEDIATED AUTOPHAGY
ISOLATED RAT HEPATOCYTES
OXIDATIVESTRESS
APOPTOSIS
TUMORIGENESIS
DEGRADATION
MECHANISM
BECLIN-1
VACUOLE
NEURONS
