摘要
目的同时检测抗环瓜氨酸肽抗体(Anti CCP抗体)和类风湿因子(RF)在类风湿关节炎(RA)中的敏感性及特异性,探讨两者联合检测在RA中的意义。方法利用以环瓜氨酸肽为抗原建立的ELISA技术及乳胶凝集试验分别检测105例RA病人、40例非RA弥慢性结缔组织病、35例非风湿性疾病中的Anti CCP抗体和RF的分布。比较两者的敏感性、特异性及两者联合检测的结果。结果Anti CCP抗体对RA的敏感性和特异性分别为42.9%、96.0%,RF对RA的敏感性和特异性分别为47.6%、56.0%。Anti CCP抗体与RF结果差异无显著性(P>0.25),Anti CCP抗体与RF的关系不密切。结论Anti CCP抗体具有良好的敏感性及特异性,Anti CCP抗体可视为RA早期诊断新的血清学指标,和RF联合检测能提高诊断RA的敏感性和特异性,将更好的诊断出可疑的早期RA病人。
Objective Analyse the sensitivity and specific of Anti-CCP antibody and RF in patients with rheumatoid arthritis,to explore the value in diagnosting RA when the two antibody were used together. Methods Distributly use the ELISA method based on CCP antigen and the latex agglutination test to examine the Anti-CCP antibody and RF in 105 RA patients,40 non-RA diffuse CTD patients and 35 non-rheumatism disease patients.Comparis the sensitivity and specific of the tow and the result that they examined together. Results The sensitivity and specific of Anti-CCP antibody to RA is 42.9% and 96.0%,while that of RF to RA is 47.6% and 56.0%.The result of both to RA has no notable difference (P>0.25),There is no close relationship between Anti-CCP antibody and RF. Conclusion Anti-CCP antibody have good sensitivity and specific,Anti-CCP antibody can be used as the new serum sign for the diagnosis of RA in early period.Analysing Anit-CCP antibody and RF together is helpful for diagnosing patients who suspected RA.
出处
《广州医药》
2005年第2期64-66,共3页
Guangzhou Medical Journal
