摘要
目的研究胍丁胺对大鼠大脑中动脉闭塞所致局部脑缺血的防治作用。方法应用生理盐水作为对照组,以神经行为学评分和脑梗死体积测定作为指标。结果胍丁胺20,40mg·kg-1静脉注射可显著缩小梗死体积,改善行为障碍。结论胍丁胺对局灶性脑缺血具有保护作用,可作为新的治疗脑缺血的药物。
Objective To study the protective effects of agmatine on focal brain ischemic injury . Methods The neurobehavioral score and infarct volume were used to evaluate the effects of agmatine and normal saline group was as control. Results Treatment with agmatine 20 or 40 mg·kg^-1 iv showed a significant reduction of cerebral infarct volume and neurobehavior disturbance improvement. Conclusion The results indicate that agmatine protects rats from ischemic neurological injury, suggesting agmatine may be a novel therapeutic medicine.
出处
《山西医科大学学报》
CAS
2005年第2期191-192,共2页
Journal of Shanxi Medical University
关键词
胍丁胺
脑缺血
脑梗死
大鼠
agmatine
brain ischemic
brain infarction
rats
