摘要
目的 探讨癌胚抗原信使核糖核酸 (CEA- m RNA)在非小细胞肺癌 (NSCL C)组织中的表达与临床的关系。方法 对 74例 NSCL C肺癌组织与 38例肺癌组织边缘的正常组织对照 ,采用反转录套式聚合酶链反应(RT- NP- PCR)技术检测 CEA- m RNA。结果 肺癌组织表达 CEA- m RNA的阳性表达率为 87.8% ,明显高于非肺癌组织 (P<0 .0 1) ,但其阳性表达与性别、年龄、临床分期、分化程度和病理类型无关 (P>0 .0 5 )。结论 检测 CEA-m RNA对肺癌的诊断具有重要的临床意义。
Objective: To evaluate the expression and clinical relationship of carcinoembryonic antigen messenger ribonucleic acid (CEA-mRNA) in non-small-cell lung cancer(NSCLC) .Methods CEA-mRNA was detected by reverse transcriptase-nested primers-polymerase chain reaction (RT-NP-PCR) in 74 cases who had NSCLC(control group) and 38 cases with the lung tissue of non-carcinoma(control group). Results The positive rate of CEA-mRNA in NSCLC(87.8%) was higher than that in control group P<0.01,The group difference was not related to sex ,age, pathology type,degree differentiation of and clinical stage (P>0.05).Conclusion The detection of CEA-mRNA is important in its clinical significance for the diagnosis of non-small cell lung cancer.
出处
《临床肺科杂志》
2005年第1期13-14,共2页
Journal of Clinical Pulmonary Medicine
关键词
非小细胞肺癌
癌胚抗原信使核糖核酸
non-small celllung carcinoma carcinoembryonic antigen messenger ribonucleic acid
